Interference with Cell-Cycle Progression by Parasitic Genetic Elements: Sleeping Beauty Joins the Club
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چکیده
منابع مشابه
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
We used the Sleeping Beauty (SB) transposable element as a tool to probe transposon-host cell interactions in vertebrates. The Miz-1 transcription factor was identified as an interactor of the SB transposase in a yeast two-hybrid screen. Through its association with Miz-1, the SB transposase down-regulates cyclin D1 expression in human cells, as evidenced by differential gene expression analysi...
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Members of the Tc1/mariner superfamily of transposable elements isolated from vertebrate species are inactive due to the accumulation of mutations. A representative of a subfamily of fish elements estimated to be last active > 10 million years ago has been reconstructed, and named Sleeping Beauty(SB). This element opened up new avenues for studies on DNA transposition in vertebrates, and for th...
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With the notable exception of David Lewis, most of those writing on the Sleeping Beauty problem have argued that 1/3 is the correct answer. Terence Horgan has provided the clearest account of why, contrary to Lewis, Beauty has evidence against the proposition that the coin comes up heads when she awakens on Monday. In this paper, I argue that Horgan’s proposal fails because it neglects importan...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2006
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.5.12.2888